Arylcyclohexylamines are noncompetitive NMDA receptor antagonists of direct action, that is, it blocks the ion channel of receptors. It depresses the neurons function in the associative cerebral cortex zone and thalamus (which switches sensory impulses from the reticular activating system to the cerebral cortex) and simultaneously stimulates parts of the limbic system (which is involved in sensory awareness), including the hippocampus. This creates functional disorganization of nonspecific connections in the middle brain and thalamus—this condition is called dissociative anesthesia. Clinically, this state is manifested by the fact that patient appears to be awake (opens his eyes, swallows, contracts muscles), but he is unable to analyze sensory stimuli and react to them. It is proved that arylcyclohexylamines inhibits the transfer of impulses in the reticular medulla oblongata formation, blocking the afferent nociceptive stimuli from the spinal cord to higher brain centers. Also arylcyclohexylamine binds to opioid receptors in the head and hindbones of the spinal cord, which can explain its analgesic effect. You can buy arylcyclohexylamines online for scientific research purposes.